Hemodynamic properties and arterial structure in male rat offspring with fetal hypothyroidism
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چکیده
منابع مشابه
Reduced uteroplacental blood flow alters renal arterial reactivity and glomerular properties in the rat offspring.
Fetal malnutrition and hypoxia may modify organ system maturation and result in cardiovascular diseases in the adult. We tested whether intrauterine stress (IUS) leads to persistent alterations of renal biology. In rats, intrauterine stress was induced by ligation of the uterine arteries at day 17 of pregnancy. Renal arteries of the 21-day-old male offspring were isolated to study pharmacologic...
متن کاملMetabolic programming of adipose tissue structure and function in male rat offspring by prenatal undernutrition
BACKGROUND A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous rat studies have shown that maternal undernutrition during pregnancy led to i...
متن کاملArterial hypertrophy in the fetal and neonatal spontaneously hypertensive rat.
Large artery dimensions in prenatal and postnatal normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were evaluated to determine whether increased medial thickness is evident during early development. Microscopic cross-sections from perfusion-fixed aortas and carotid arteries of fetal (22-day gestation) and neonatal (5-day-old) animals were examined for numbers of la...
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ژورنال
عنوان ژورنال: General physiology and biophysics
سال: 2016
ISSN: 1338-4325
DOI: 10.4149/gpb_2016018